Ressources scientifiques
Akram Khan M., Afzal M. Chemical composition of Nigella sativa Linn: Part 2 Recent advances.
Inflammopharmacology, 2016, 24(2-3):67-79. doi: 10.1007/s10787-016-0262-7.
Ali B.H., Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother. Res., 2003, 17,
299-305.
Alkhatib H. et al. Thymoquinone content in marketed black seed oil in Malaysia. J Pharm Bioallied Sci. 2020,
12(3): 284–288. doi: 10.4103/jpbs.JPBS_208_20
Alshwyeh H.A., Aldosary S.K., Ilowefah M.A., Shahzad R., Shehzad A., Bilal S., Lee I.-J., Mater J.A.A., Al-Shakhoari
F.N., Alqahtani W.A., Kamal N., Mediani A. Biological Potentials and Phytochemical Constituents of Raw and
Roasted Nigella arvensis and Nigella sativa. Molecules 2022, 27, 550.
https://doi.org/10.3390/molecules27020550
Alzohairy MA, Khan AA, Alsahli MA, Almatroodi SA, Rahmani AH. Protective Effects of Thymoquinone, an Active
Compound of Nigella sativa, on Rats with Benzo(a)pyrene-Induced Lung Injury through Regulation of Oxidative
Stress and Inflammation. Molecules. 2021; 26(11):3218. https://doi.org/10.3390/molecules26113218
Amin B., Hosseinzadeh H. Black Cumin (Nigella sativa) and Its Active Constituent, Thymoquinone: An Overview
on the Analgesic and Anti-inflammatory Effects. Planta Med. 2016, 82(1-2):8-16. doi: 10.1055/s-0035-1557838.
Ansary J, Giampieri F, Forbes-Hernandez TY, Regolo L, Quinzi D, Gracia Villar S, Garcia Villena E, Tutusaus Pifarre
K, Alvarez-Suarez JM, Battino M, Cianciosi D. Nutritional Value and Preventive Role of Nigella sativa L. and Its
Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies.
Molecules. 2021; 26(8): 2108. https://doi.org/10.3390/molecules26082108
Anses, 2018. Avis de l’Anses : État des lieux des alternatives aux antibiotiques en vue de diminuer leur usage en
élevage : Élaboration d’une méthode d’évaluation des publications scientifiques et résultats. Rapport
d’expertise collective, février 2018, Saisine n° 2013-SA-0122.
Anses, 2021. Note d’appui scientifique et technique de l’Agence nationale de sécurité sanitaire de
l’alimentation, de l’environnement et du travail relative aux plantes et huiles essentielles les plus impliquées
dans les déclarations de nutrivigilance signalées à l’Anses, 17 décembre 2021. Appui scientifique et technique
de l’Anses, Demande n° « 2021-AST-0133 »
Anses, 2021. Phytothérapie et aromathérapie chez les animaux producteurs de denrées alimentaires.
Proposition d’une méthodologie d’évaluation du risque pour le consommateur, Rapport d’expertise collective,
Décembre 2021, Saisine n° 2020-SA-0083, https://www.anses.fr/fr/system/files/ERCA2020SA0083Ra.pdf
ANSM, 2021 : Liste A des plantes médicinales utilisées traditionnellement (16/01/2021) ; Liste B des plantes
médicinales utilisées traditionnellement en l’état ou sous forme de préparation dont les effets indésirables
potentiels sont supérieurs au bénéfice thérapeutique attendu (16/01/2021)
https://ansm.sante.fr/pharmacopee/liste-des-plantes-medicinales-utilisees-traditionnellement#L
Aronson JK (Ed). Meyler’s Side Effects of Herbal Medicines, 2e ed., 2009, Elsevier ed.
Arrêté du 4 octobre 2019 portant radiation de médicaments homéopathiques de la liste des spécialités
pharmaceutiques remboursables aux assurés sociaux mentionnée au premier alinéa de l’article L. 162-17 du
code de la sécurité sociale, Journal Officiel de la République Française du 8 octobre 2019.
ARRETE ROYAL du 29 AOUT 1997 relatif à la fabrication et au commerce de denrées alimentaires composées ou
contenant des plantes ou préparations de plantes (Moniteur Belge 21.XI.1997), version consolidée 2017 par
A.R. du 24 janvier 2017 (Moniteur Belge 10.II.2017).
Ayurvedic Pharmacopoeia of India – Plants Monographs (vol. 1) : disponible à :
http://www.ayurveda.hu/api/API-Vol-1.pdf
Barnes et al. (Ed), 2007. Herbal medicines. 2e éd. Pharmaceutical Press ; Barnes J., Anderson L.A., Phillipson J.D.
Herbal medicines. 3e éd. Pharmaceutical Press.
46
Botnick I, Xue W, Bar E, Ibdah M, Schwartz A, Joel DM, Lev E, Fait A, Lewinsohn E. Distribution of primary and
specialized metabolites in Nigella sativa seeds, a spice with vast traditional and historical uses. Molecules. 2012
; 17(9): 10159-77. doi: 10.3390/molecules170910159.
Bruneton J. 2016. Pharmacognosie, phytochimie, plantes médicinales. 5e édition, Éditions Tec et Doc, Lavoisier.
Bruneton J., 2002. Phytothérapie : les données de l’évaluation. Éditions Tec et Doc, Lavoisier.
Burdock G.A. Assessment of black cumin (Nigella sativa L.) as a food ingredient and putative therapeutic agent.
Regul Toxicol Pharmacol. 2022, 128:105088. doi: 10.1016/j.yrtph.2021.105088.
Butt MS, Imran M, Imran A, Arshad MS, Saeed F, Gondal TA, Shariati MA, Gilani SA, Tufail T, Ahmad I, Rind NA,
Mahomoodally MF, Islam S, Mehmood Z. Therapeutic perspective of thymoquinone: A mechanistic treatise.
Food Sci Nutr. 2021; 9(3): 1792-1809. doi: 10.1002/fsn3.2070.
Capasso F., Gaginella T. S., Grandolini G., Izzo A.A., 2003. Phytotherapy – A quick reference to herbal medicine.
Springer.
Cheikh-Rouhou S., Besbes S., Hentati B., Blecker C., Deroanne C., Attia H. Nigella sativa L. Chemical composition
and phytochemical characteristics of lipid fraction. Food Chem., 2007, 101, 673-681.
Commission Européenne. Register of Feed Additives pursuant to Regulation (EC) N° 1831/2003. Version 2020.
ISBN 978-92-79-67663-5, doi: 10.2875/48257
Commission Européenne. RÈGLEMENT (CE) No 1334/2008 DU PARLEMENT EUROPÉEN ET DU CONSEIL du 16
décembre 2008 relatif aux arômes et à certains ingrédients alimentaires possédant des propriétés
aromatisantes qui sont destinés à être utilisés dans et sur les denrées alimentaires et modifiant le règlement
(CEE) no 1601/91 du Conseil, les règlements (CE) no 2232/96 et (CE) no 110/2008 et la directive 2000/13/CE,
Journal Officiel de l’Union Européenne, 31.12.2008.
Dalli M, Bekkouch O, Azizi S-e, Azghar A, Gseyra N, Kim B. Nigella sativa L. Phytochemistry and Pharmacological
Activities: A Review (2019–2021). Biomolecules. 2022; 12(1):20. https://doi.org/10.3390/biom12010020
DGCCRF, 2016. Liste des plantes éligibles à l’article 15.
https://www.economie.gouv.fr/files/files/directions_services/dgccrf/securite/teleicare/Table-Plantes.pdf
DGCCRF, 2019 : Liste des plantes dont sont extraites des huiles essentielles dont l’usage en alimentation
humaine est considéré comme étant traditionnel, au sens de l’article 7 du décret n°2006-352 relatif aux
compléments alimentaires et Liste des huiles essentielles dont l’emploi ne peut être admis.
https://www.economie.gouv.fr/dgccrf/complements-alimentaires-plantes
Dobetsberger C., Buchbauer G. Actions of essential oils on the central nervous system: An updated review.
Flavour Fragr. J. 2011, 26, 300–316. DOI 10.1002/ffj.2045
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), Younes M, Aggett P, Aguilar F,
Crebelli R, Dusemund B, Filipič M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Lambré C, Leblanc JC,
Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA,
Andrade RJ, Fortes C, Mosesso P, Restani P, Arcella D, Pizzo F, Smeraldi C, Wright M. Scientific opinion on the
safety of green tea catechins. EFSA J. 2018; 16(4): e05239. doi: 10.2903/j.efsa.2018.5239.
Essid R., Rahali F. Z., Msaada K., Sghair I., Hammami M., Bouratbine A., Aoun K., Limam F. Ind. Crops. Prod.
2015, 77, 795-802.
European Food Safety Authority; Compendium of botanicals reported to contain naturally occurring substances
of possible concern for human health when used in food and food supplements. EFSA Journal 2012;10(5):2663.
[60 pp.] doi:10.2903/j.efsa.2012.2663.
European Food Safety Authority; Compendium of botanicals that have been reported to contain toxic,
addictive, psychotropic or other substances of concern on request of EFSA. EFSA Journal 2009; 7(9):281. [100
pp.]. doi:10.2903/j.efsa.2009.281.
Evans W., 2009. Trease and Evans’ pharmacognosy, 16th ed. Saunders.
Farag MA, Gad HA, Heiss AG, Wessjohann LA. Metabolomics driven analysis of six Nigella species seeds via
UPLC-qTOF-MS and GC-MS coupled to chemometrics. Food Chem. 2014 ; 151: 333-42. doi:
10.1016/j.foodchem.2013.11.032.
47
FDA, CFR – Code of Federal Regulations Title 21 (version en vigueur le 1er octobre 2021) : Code of Federal
Regulations] [Title 21, Volume 3] [CITE: 21CFR182.10] SUBCHAPTER B – FOOD FOR HUMAN CONSUMPTION;
PART 182 — SUBSTANCES GENERALLY RECOGNIZED AS SAFE, Subpart A – General Provisions, Sec. 182.10 Spices
and other natural seasonings and flavorings : “Caraway, black (black cumin), Nigella sativa L.”
Franchomme P., Jollois R., Pénoël D. L’aromathérapie exactement. Editions R. JOLLOIS, 2003 (EAN :
9782878190014).
Gardner Z, McGuffin M. Botanical Safety Handbook, 2nd Edition, 2013, AHPA ed.
Ghanya N. Al-Naqeep, Maznah M. Ismail, Adel S. Al-Zubairi and Norhaizan M. Esa. Nutrients Composition and
Minerals Content of Three Different Samples of Nigella sativa L. Cultivated in Yemen. Asian Journal of Biological
Sciences, 2009, 2: 43-48.
Gharby S., et al. Chemical investigation of Nigella sativa L. seed oil produced in Morocco. Journal of the Saudi
Society of Agricultural Sciences, 2015, 14(2), 172-177, https://doi.org/10.1016/j.jssas.2013.12.001
Hadi V, Pahlavani N, Malekahmadi M, Nattagh-Eshtivani E, Navashenaq JG, Hadi S, et al. Nigella sativa in
controlling Type 2 diabetes, cardiovascular, and rheumatoid arthritis diseases: Molecular aspects. J Res Med Sci
2021; 26: 20.
Hadi V. et al. Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status
in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. Avicenna J.
Phytomed. 2016;6(1):34-43.
Han A., Shi D. The efficacy of Nigella sativa supplementation for asthma control: a meta-analysis of randomized
controlled studies. Adv Dermatol Allergol 2021; XXXVIII (4): 561–565. doi:
https://doi.org/10.5114/ada.2020.93220
Hannan MA, Rahman MA, Sohag AAM, Uddin MJ, Dash R, Sikder MH, Rahman MS, Timalsina B, Munni YA,
Sarker PP, Alam M, Mohibbullah M, Haque MN, Jahan I, Hossain MT, Afrin T, Rahman MM, Tahjib-Ul-Arif M,
Mitra S, Oktaviani DF, Khan MK, Choi HJ, Moon IS, Kim B. Black Cumin (Nigella sativa L.): A Comprehensive
Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety. Nutrients. 2021; 13(6):1784.
https://doi.org/10.3390/nu13061784
Hannan MA, Zahan MS, Sarker PP, Moni A, Ha H, Uddin MJ. Protective Effects of Black Cumin (Nigella sativa)
and Its Bioactive Constituent, Thymoquinone against Kidney Injury: An Aspect on Pharmacological Insights.
International Journal of Molecular Sciences. 2021; 22(16): 9078. https://doi.org/10.3390/ijms22169078
Heinrich M., Barnes J., Gibbons S., Williamson E.M., 2012. Fundamentals of pharmacognosy and phytotherapy.
Elsevier.
Hossain MS, Sharfaraz A, Dutta A, Ahsan A, Masud MA, Ahmed IA, Goh BH, Urbi Z, Sarker MMR, Ming LC. A
review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L. Biomed
Pharmacother. 2021; 143:112182. doi: 10.1016/j.biopha.2021.112182.
Hwang, Cartron, Khachemoune. A review of Nigella sativa plant-based therapy in dermatology. International
Journal of Dermatology 2021, 60, e493–e499. doi: 10.1111/ijd.15615
Kabir Y, Akasaka-Hashimoto Y, Kubota K, Komai M. Volatile compounds of black cumin (Nigella sativa L.) seeds
cultivated in Bangladesh and India. Heliyon. 2020, 6(10):e05343. doi: 10.1016/j.heliyon.2020.e05343.
Khabbazi A, Javadivala Z, Seyedsadjadi N, Malek Mahdavi A. A Systematic Review of the Potential Effects of
Nigella sativa on Rheumatoid Arthritis. Planta Med. 2020; 86(7): 457-469. doi: 10.1055/a-1143-8521.
Khare C.P. Ayurvedic Pharmacopoeial plant drugs – expanded therapeutics, CRC Press, 2016, ISBN 978-1-4665-
9000-7 (e-book)
Kheirouri S, Hadi V, Alizadeh M. Immunomodulatory Effect of Nigella sativa Oil on T Lymphocytes in Patients
with Rheumatoid Arthritis. Immunol Invest. 2016, 45(4):271-83. doi: 10.3109/08820139.2016.1153649.
Khonche A, Huseini HF, Gholamian M, Mohtashami R, Nabati F, Kianbakht S. Standardized Nigella sativa seed
oil ameliorates hepatic steatosis, aminotransferase and lipid levels in non-alcoholic fatty liver disease: a
randomized, double-blind and placebo-controlled clinical trial. J Ethnopharmacol. 2019;234:106–11.
48
Koshak A. et al. Medicinal benefits of Nigella sativa in bronchial asthma: A literature review. Saudi Pharm J.
2017, 25(8):1130-1136. doi: 10.1016/j.jsps.2017.07.002.
Leong X.-F. et al. Anti-Inflammatory Effects of Thymoquinone in Atherosclerosis: A Mini Review. Front
Pharmacol. 2021; 12: 758929. doi: 10.3389/fphar.2021.758929
Mahboubi M, Mohammad Taghizadeh Kashani L, Mahboubi M. Nigella sativa fixed oil as alternative treatment
in management of pain in arthritis rheumatoid. Phytomedicine. 2018; 46: 69-77. doi:
10.1016/j.phymed.2018.04.018.
Mahdavi R. et al. Nigella sativa oil with a calorie-restricted diet can improve biomarkers of systemic
inflammation in obese women: A randomized double-blind, placebo-controlled clinical trial. J Clin Lipidol 2016,
10(5):1203-11. doi: 10.1016/j.jacl.2015.11.019.
Mahmoudvand H., Tavakoli R., Sharififar F., Minaie K., Ezatpour B., Jahanbakhsh S., Sharifi I. Pharm. Biol. 2015,
53, 1052-1057.
Majdalawieh A.F., Fayyad M.W. Immunomodulatory and anti-inflammatory action of Nigella sativa and
thymoquinone: A comprehensive review. International Immunopharmacology 2015, 28, 295–304. doi:
10.1016/j.intimp.2015.06.023.
Majdalawieh AF, Yousef SM, Abu-Yousef IA. Thymoquinone, a major constituent in Nigella sativa seeds, is a
potential preventive and treatment option for atherosclerosis. Eur J Pharmacol. 2021; 909: 174420. doi:
10.1016/j.ejphar.2021.174420.
Malekian S, Ghassab-Abdollahi N, Mirghafourvand M, Farshbaf-Khalili A. The effect of Nigella sativa on
oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis. J Complement Integr
Med. 2021 ;18(2):235-259. doi: 10.1515/jcim-2019-0198.
Malik S, Singh A, Negi P, Kapoor VK. Thymoquinone: A small molecule from nature with high therapeutic
potential. Drug Discov Today. 2021; 26(11): 2716-2725. doi: 10.1016/j.drudis.2021.07.013.
Marsik P. et al. In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1-
and -2-catalyzed prostaglandin E2 biosyntheses. Planta Med. 2005, 71(8):739-42. doi: 10.1055/s-2005-871288.
Melo F. H., Venâncio E. T., de Sousa D. P., França Fonteles M. M., de Vasconcelos S. M., Viana G. S., de Sousa F.
Fundam. Clin. Pharmacol. 2009. 24(4), 437
Ministero della Salute. Allegato 1 al DM 10 agosto 2018 sulla disciplina dell’impiego negli integratori alimentari
di Sostanze e preparati vegetali come aggiornato con Decreto 9 gennaio 2018 e da ultimo con Decreto 26 luglio
2019.
Mohammed N.K. et al. The Effects of Different Extraction Methods on Antioxidant Properties, Chemical
Composition, and Thermal Behavior of Black Seed (Nigella sativa L.) Oil. Evidence-Based Complementary and
Alternative Medicine, 2016, article ID 6273817; https://doi.org/10.1155/2016/6273817
Montazeri RS, Fatahi S, Sohouli MH, Abu-Zaid A, Santos HO, Găman MA, Shidfar F. The effect of Nigella sativa
on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized
controlled trials. J Food Biochem. 2021;45(4):e13625. doi: 10.1111/jfbc.13625.
Nawarathne et al. Development of Novel Topical Cosmeceutical Formulations from Nigella sativa L. with
Antimicrobial Activity against Acne-Causing Microorganisms. The Scientific World Journal, 2019, article ID
5985207, doi: 10.1155/2019/5985207.
Paris R.R., Moyse H. Matière médicale (3 tomes). 3
e éd, 1971. Masson Ed.
Pelkonen, O., Duez, P., Vuorela, P.M., Vuorela, H. (Eds.). Toxicology of Herbal Products. 2017, Springer ed.
Perveen T., Haider S., Kanwal S., Haleem D. J., Pakistan J. Pharm. Sci. 2009, 22, 139.
Raza, M.; Alghasham, A.A.; Alorainy, M.S.; El-Hadiyah, T.M. Potentiation of Valproate-induced Anticonvulsant
Response by Nigella sativa Seed Constituents: The Role of GABA Receptors. Int. J. Health Sci. 2008, 2, 15–25.
Rouhou S. Cheikh, Besbes S., Hentati B., Blecker C., Deroanne C., Attia H. Nigella sativa L. Chemical composition
and phytochemical characteristics of lipid fraction. Food Chem., 2007, 101, 673-681.
49
Sahebkar A, Beccuti G, Simental-Mendía LE, Nobili V, Bo S. Nigella sativa (black seed) effects on plasma lipid
concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials.
Pharmacol Res. 2016; 106: 37-50. doi: 10.1016/j.phrs.2016.02.008.
Saima A., Showkat R., Kanchan K., Babar A., Mohad A. A study of the chemical composition of black cumin oil
and its effect on penetratin enhancement from transdermal formulation. Nat. Prod.Res. 2010, 24(12), 1151–
1157.
Salehi B, Quispe C, Imran M, Ul-Haq I, Živković J, Abu-Reidah IM, Sen S, Taheri Y, Acharya K, Azadi H, Del Mar
Contreras M, Segura-Carretero A, Mnayer D, Sethi G, Martorell M, Abdull Razis AF, Sunusi U, Kamal RM, Rasul
Suleria HA, Sharifi-Rad J. Nigella Plants – Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical
Studies. Front Pharmacol. 2021; 12:625386. doi: 10.3389/fphar.2021.625386.
Sarkar C, Jamaddar S, Islam T, Mondal M, Islam MT, Mubarak MS. Therapeutic perspectives of the black cumin
component thymoquinone: A review. Food Funct. 2021 ; 12(14): 6167-6213. doi: 10.1039/d1fo00401h.
Singh S, Das SS, Singh G, Schuff C, de Lampasona MP, Catalán CA. Composition, in vitro antioxidant and
antimicrobial activities of essential oil and oleoresins obtained from black cumin seeds (Nigella sativa L.).
Biomed Res Int. 2014; 2014: 918209. doi: 10.1155/2014/918209.
Soleymani S. et al. The effect of a hydrogel made by Nigella sativa L. on acne vulgaris: A randomized double-
blind clinical trial. Phytother. Res. 2020, 34(11):3052-3062. doi: 10.1002/ptr.6739.
© Tous droits réservés